A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 4K citations

Life Sciences, Biotechnology, Immunology +14

Somatic generation of antibody diversity.

PubMed · 1976 · 3.3K citations

Life Sciences, Biotechnology, Immunology +14

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

Julian Banerji, Laura Olson, Walter Schaffner · Cell · 1983 · 1.5K citations

Life Sciences, Genetics, Immunology +14

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

Stephen D. Gillies, Sherie L. Morrison, Vernon T. Oi et al. · Cell · 1983 · 1.4K citations

Medicine, Genetics, Molecular Genetics +16

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

Hitoshi Sakano, Richard A. Maki, Yoshikazu Kurosawa et al. · Nature · 1980 · 797 citations

Life Sciences, Immunology, Molecular Biology +11