Somatic generation of antibody diversity

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

Tai Te Wu, Elvin A. Kabat · The Journal of Experimental Medicine · 1970 · 1.3K citations · Full text

Life Sciences, Biochemistry, Immunology +17

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

P. Early · Cell · 1980 · 888 citations

Life Sciences, Genetics, Molecular Biology +9

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

P. Early, Huarong Huang, Mark M. Davis et al. · Cell · 1980 · 868 citations

Life Sciences, Genetics, Molecular Genetics +6

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

Hitoshi Sakano, Konrad Hüppi, Günther Heinrich et al. · Nature · 1979 · 855 citations

Life Sciences, Molecular Biology, Molecular Genetics +14

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

Hitoshi Sakano, Richard A. Maki, Yoshikazu Kurosawa et al. · Nature · 1980 · 797 citations

Life Sciences, Immunology, Molecular Biology +11