Concepedia

Somatic Diversity Generation

Somatic Diversity Generation is a biological mechanism in the adaptive immune system that, through the site-specific recombination of variable (V), diversity (D), and joining (J) gene segments in developing lymphocytes, uniquely generates a vast repertoire of antigen receptor specificities during an organism's lifetime.

28

Publications

5.8K

Citations

93

Authors

46

Institutions

Publications per year

2017–2026

3

Parents

Publications

28

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 4K citations

, , +14

Somatic generation of antibody diversity.

PubMed · 1976 · 3.3K citations

, , +14

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

Andrew S. Greenberg, David Ávila, Marianne K. Hughes et al. · Nature · 1995 · 757 citations

, , +16

Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches

Claude–Agnès Reynaud, Charles R. Mackay, Rolf G. Müller et al. · Cell · 1991 · 271 citations

, , +16

Evidence for Somatic Generation of Antibody Diversity

Susumu Tonegawa, C M Steinberg, Shyam K. Dube et al. · Proceedings of the National Academy of Sciences · 1974 · 160 citations · Full text

, , +14

1–5 of 28

Authors

93

  1. ST
    Susumu Tonegawa

    Massachusetts Institute of Technology, United States

    3 publications · 293 citations

    3

    h-index

  2. LT
    Linda Taylor

    Commonwealth Scientific and Industrial Research Organisation, Australia

    2 publications · 222 citations

    2

    h-index

  3. EJ
    Edward J. Steele

    University of Wollongong, Australia

    2 publications · 222 citations

    2

    h-index

  4. PS
    Philip Schulman

    North Shore University Hospital, United States

    1 publications · 138 citations

    1

    h-index

  5. LB
    Lesley Berghuis

    Memorial University of Newfoundland, Canada

    1 publications · 38 citations

    1

    h-index

1–5 of 93

Institutions

46

  1. National Institutes of Health

    Bethesda, United States

    3 h-index

    5 publications

    186 citations

  2. Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    2 h-index

    7 publications

    759 citations

  3. Albert Einstein College of Medicine

    Bronx, United States

    2 h-index

    5 publications

    501 citations

  4. Yeshiva University

    New York, United States

    2 h-index

    5 publications

    501 citations

  5. Max Planck Institute of Immunobiology and Epigenetics

    Freiburg, Germany

    2 h-index

    9 publications

    326 citations

  6. University of Wollongong

    Wollongong, Australia

    2 h-index

    5 publications

    501 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    2 publications

    3.4K citations

  8. Center for Cancer Research

    Bethesda, United States

    2 h-index

    2 publications

    3.4K citations

1–8 of 46

Venues

  1. PubMed

    Repository · 4 publications · 3.3K citations

    4

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 316 citations

    3

    h-index

  3. Cell

    3 publications · 447 citations

    3

    h-index

  4. Molecular and Cellular Biology

    MCB · 2 publications · 222 citations

    2

    h-index

  5. 2

    h-index

1–5