Modern Therapeutic Approaches in Metastatic Renal Cell Carcinoma

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

Mutations of the VHL tumour suppressor gene in renal carcinoma

James R. Gnarra, Kálmán Tory, Y Weng et al. · Nature Genetics · 1994 · 1.7K citations

Medicine, Genetics, Molecular Genetics +14

Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer

Robert C. Flanigan, Sydney E. Salmon, Brent A. Blumenstein et al. · New England Journal of Medicine · 2001 · 1.7K citations

Medicine, Oncology, Surgery +16

Activity of SU11248, a Multitargeted Inhibitor of Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor, in Patients With Metastatic Renal Cell Carcinoma

Robert J. Motzer, M. Dror Michaelson, Bruce G. Redman et al. · Journal of Clinical Oncology · 2005 · 1.6K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Michael Ohh, Cheol Won Park, Mircea Ivan et al. · Nature Cell Biology · 2000 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +12