Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +12

Congenital leptin deficiency is associated with severe early-onset obesity in humans

I. Sadaf Farooqi, Jonathan P. Whitehead, Maria A. Soos et al. · Nature · 1997 · 2.9K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +10

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Karine Clément, Christian Vaisse, Najiba Lahlou et al. · Nature · 1998 · 2.4K citations

Obesity, Metabolic Syndrome, Endocrine Mechanism +10

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Heiko Krude, Heike Biebermann, W. A. P. Luck et al. · Nature Genetics · 1998 · 1.7K citations

Obesity, Metabolic Syndrome, Severe Early-onset Obesity +8

A leptin missense mutation associated with hypogonadism and morbid obesity

Andreas Strobel, Tarik Issad, Luc Camoin et al. · Nature Genetics · 1998 · 1.2K citations

Obesity, Metabolic Syndrome, Growth Hormone +9