Covalent Reactions of Wortmannin under Physiological Conditions

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Edward H. Walker, Michael E. Pacold, Olga Perišić et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Molecular Pharmacology, Signal Transduction, Biochemistry +11

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.1K citations · Full text

Molecular Pharmacology, Metabolic Syndrome, Signal Transduction +14

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara et al. · Journal of Biological Chemistry · 1994 · 918 citations · Full text

Insulin Receptor, Insulin Signaling, Molecular Pharmacology +19

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

Matthias P. Wymann, Ginette Bulgarelli-Leva, Marketa Zvelebil et al. · Molecular and Cellular Biology · 1996 · 677 citations · Full text

Signal Transduction, Biochemistry, Natural Sciences +13

PI 3-kinase p110β: a new target for antithrombotic therapy

Shaun P. Jackson, Simone M. Schoenwaelder, Isaac Goncalves et al. · Nature Medicine · 2005 · 588 citations

Thrombosis, Medicine, Pi 3-Kinase P110β +5