Concepedia

The Novel IKK2 Inhibitor LY2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NF-κB

Changchun Deng, Mark Lipstein, Richard Rodríguez, Xavier O. Jirau Serrano, Christine McIntosh, Wei‐Yann Tsai, Andrew S. Wasmuth, Susan Jaken, Owen A. O’Connor

Clinical Cancer Research · 2014 · 25 citations · 34 references

DOI

Abstract

Collectively, these data strongly suggest that targeting the NF-κB pathway in combination with romidepsin could represent a novel and potent regimen for the treatment of B- and T-cell lymphoma.

References

34

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The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma

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Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Lin‐Feng Chen, Wolfgang Fischle, Eric Verdin et al. · Science · 2001 · 1.2K citations · Full text

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Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

R. Eric Davis, Keith Brown, Ulrich Siebenlist et al. · The Journal of Experimental Medicine · 2001 · 1K citations · Full text

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Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

Mara Compagno, Wei Keat Lim, Adina Grunn et al. · Nature · 2009 · 1K citations · Full text

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