Concepedia

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

Lise Willems, Nicolas Chapuis, Alexandre Puissant, Thiago Trovati Maciel, Alexa S. Green, Nathalie Jacque, Christine Vignon, Sophie Park, Sylvie M. Guichard, Olivier Hérault,

Leukemia · 2011 · 161 citations · 32 references

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References

32

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Dos D. Sarbassov, Siraj M. Ali, Do‐Hyung Kim et al. · Current Biology · 2004 · 2.7K citations · Full text

, , +12

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Estela Jacinto, Robbie Loewith, Anja Schmidt et al. · Nature Cell Biology · 2004 · 2.1K citations

, , +14

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Arkaitz Carracedo, Li Ma, Julie Teruya‐Feldstein et al. · Journal of Clinical Investigation · 2008 · 1.4K citations · Full text

, , +17