Concepedia

Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

Tsutomu Yokomatsu, Hiroshi Abe, Mutsumi Sato, Kenji Suemune, Taro Kihara, Shinji Soeda, Hiroshi Shimeno, Shiroshi Shibuya

Bioorganic & Medicinal Chemistry · 1998 · 39 citations · 21 references

DOI

Concepts

References

21

Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.

S.E. Ealick, Y.S. Babu, Charles E. Bugg et al. · Proceedings of the National Academy of Sciences · 1991 · 152 citations

, , +16

9-(Difluorophosphonoalkyl)guanines as a new class of multisubstrate analog inhibitors of purine nucleoside phosphorylase

Serge Halazy, Anne Ehrhard, Charles Danzin · Journal of the American Chemical Society · 1991 · 131 citations

, , +10

Synthesis of Potential Anticancer Agents. XXVI. The Alkylation of 6-Chloropurine<sup>2</sup>

John A. Montgomery, Carroll Temple · Journal of the American Chemical Society · 1961 · 121 citations

, , +10

[72] Purine nucleoside phosphorylase from human erythrocytes

Johanna D. Stoeckler, R. P. Agarwal, Khushboo Agarwal et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 1978 · 120 citations

, , +10

Characterization of N7 and N9 alkylated purine analogues by 1H and 13C nmr

J. Kjellberg, Nils Gunnar Johansson · Tetrahedron · 1986 · 102 citations

, , +7