Concepedia

Purine Biosynthesis

Purine Biosynthesis is a de novo anabolic pathway in nucleotide metabolism that constructs the purine ring system on a phosphoribose backbone through a series of enzyme-catalyzed reactions, distinguished from salvage pathways by its reliance on one-carbon units and amino group donors to build the purine structure from simple precursors.

2K

Publications

92.7K

Citations

6.5K

Authors

1.4K

Institutions

Publications per year

2017–2026

213

Parents

Publications

2K

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Edwin Seegmiller, Frederick M. Rosenbloom, William N. Kelley · Science · 1967 · 1.2K citations

, , +14

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Issam Ben‐Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult et al. · Science · 2016 · 795 citations

, , +17

Proline: a key player in plant abiotic stress tolerance

Gagandeep Kaur, Bavita Asthir · Biologia Plantarum · 2015 · 694 citations

, , +15

Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.

Daniel R. Rhodes, Terrence R. Barrette, Mark A. Rubin et al. · PubMed · 2002 · 663 citations

, , +17

A RANDOMIZED ACTIVE-CONTROLLED TRIAL OF MYCOPHENOLATE MOFETIL IN HEART TRANSPLANT RECIPIENTS1

Jon Kobashigawa, Dale G. Renlund, Robert M. Mentzer et al. · Transplantation · 1998 · 616 citations

, , +17

1–5 of 2K

Authors

6.5K

  1. JM
    John M. Buchanan

    Massachusetts Institute of Technology, United States

    37 publications · 2.4K citations

    34

    h-index

  2. SJ
    Stephen J. Benkovic

    Pennsylvania State University, United States

    30 publications · 2.5K citations

    25

    h-index

  3. RK
    Roland K. Robins

    Brigham Young University, United States

    31 publications · 1.5K citations

    22

    h-index

  4. JE
    J. Edwin Seegmiller

    University of California San Diego, United States

    25 publications · 2.8K citations

    20

    h-index

  5. PN
    Per Nygaard

    University of Copenhagen, Denmark

    18 publications · 1K citations

    17

    h-index

1–5 of 6.5K

Institutions

1.4K

  1. Massachusetts Institute of Technology

    Cambridge, United States

    34 h-index

    127 publications

    7.9K citations

  2. University of Wisconsin–Madison

    Madison, United States

    29 h-index

    114 publications

    4.9K citations

  3. University of California San Diego

    San Diego, United States

    29 h-index

    140 publications

    8.8K citations

  4. University of Pennsylvania

    Philadelphia, United States

    27 h-index

    85 publications

    4.1K citations

  5. Pennsylvania State University

    State College, United States

    26 h-index

    109 publications

    9.7K citations

  6. Cornell University

    Ithaca, United States

    22 h-index

    104 publications

    5K citations

  7. Yale University

    New Haven, United States

    22 h-index

    68 publications

    3.3K citations

  8. Harvard University

    Cambridge, United States

    22 h-index

    64 publications

    7.4K citations

1–8 of 1.4K

Venues

  1. Journal of Biological Chemistry

    JBC · 221 publications · 13.8K citations

    70

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  2. PubMed

    Repository · 119 publications · 5.2K citations

    39

    h-index

  3. Journal of Bacteriology

    JB · 93 publications · 3.8K citations

    38

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 42 publications · 2.9K citations

    32

    h-index

  5. Biochemistry

    60 publications · 2.6K citations

    31

    h-index

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