The Journal of Antibiotics · 1993 · 21 citations · 19 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoverySynthetic Medicinal ChemistryVirologyAntiviral AgentsAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyViral InfectionsAntiviral Drug DesignAntiviral Structure-activity RelationshipsAntiviral TherapeuticsInfluenza Antiviral TherapyInfluenza Treatment
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.
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Rational design of potent sialidase-based inhibitors of influenza virus replication
Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations