Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran

Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin

Daniel H. Doherty, Michael P. Doyle, Shawn R. Curry et al. · Nature Biotechnology · 1998 · 429 citations

Hypertension, Heme Homeostasis, Reactive Nitrogen Specie +11

A clinical safety trial of stroma‐free hemoglobin

J. Philip Savitsky, John Doczi, Jack Black et al. · Clinical Pharmacology & Therapeutics · 1978 · 357 citations

Sfh Infusions, Thrombosis, Venous Thrombosis +16

An enzymic reduction system for metmyoglobin and methemoglobin, and its application to functional studies of oxygen carriers

Akira Hayashi, T. Suzuki, Masateru Shin · Biochimica et Biophysica Acta (BBA) - Protein Structure · 1973 · 329 citations

Functional Studies, Biochemistry, Heme Homeostasis +9

A human recombinant haemoglobin designed for use as a blood substitute

Douglas L. Looker, Debbie Abbott‐Brown, Paul Cozart et al. · Nature · 1992 · 313 citations

Medicine, Human Recombinant Haemoglobin, Hematology +8

Arterial Blood Pressure Responses to Cell-free Hemoglobin Solutions and the Reaction with Nitric Oxide

Ronald J. Rohlfs, Eric L. Bruner, Albert Chiu et al. · Journal of Biological Chemistry · 1998 · 276 citations · Full text