Concepedia

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

Elisabeth H. Weiss, Benjamin G. Lilienfeld, Sigrid Müller, Elfriede Müller, Nadja Herbach, Barbara Keler, Rüdiger Wanke, Reinhard Schwinzer, Jörg D. Seebach, Eckhard Wolf

Transplantation · 2009 · 153 citations · 31 references

DOI

Abstract

This novel approach against cell-mediated xenogeneic responses has important implications for the generation of multitransgenic pigs as organ donors for clinical xenotransplantation.

References

31

Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning

Liangxue Lai, Donna Kolber‐Simonds, Kwang‐Wook Park et al. · Science · 2002 · 1.3K citations

Production of α1,3-Galactosyltransferase-Deficient Pigs

Carol J. Phelps, Chihiro Koike, Todd Vaught et al. · Science · 2003 · 1.1K citations

Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience

Kenji Kuwaki, Yau‐Lin Tseng, Frank J. M. F. Dor et al. · Nature Medicine · 2004 · 690 citations

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Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Kazuhiko Yamada, Koji Yazawa, Akira Shimizu et al. · Nature Medicine · 2004 · 600 citations

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HLA-E Surface Expression Depends on Binding of TAP-Dependent Peptides Derived from Certain HLA Class I Signal Sequences

Ni Lee, David R. Goodlett, Akiko Ishitani et al. · The Journal of Immunology · 1998 · 498 citations · Full text