Importance of protein thiols during N-methyl-N′-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes

Methylation of deoxyribonucleic acid in cultured mammalian cells by <i>N</i>-methyl-<i>N</i>′-nitro-<i>N</i>-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

P.D. Lawley, Carolyn J. Thatcher · Biochemical Journal · 1970 · 495 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

Donato A. Di Monte, David Ross, Giorgio Bellomo et al. · Archives of Biochemistry and Biophysics · 1984 · 411 citations

Life Sciences, Biochemistry, Physiology +13

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

Donato A. Di Monte, Giorgio Bellomo, Hjördis Thor et al. · Archives of Biochemistry and Biophysics · 1984 · 375 citations

Life Sciences, Biochemistry, Pharmacology +13

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

Emanuele Albano, Mats Rundgren, Peter J. Harvison et al. · Molecular Pharmacology · 1985 · 313 citations

Pharmacy, Biochemistry, Toxicology +17