Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1α in essential hypertension

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Medicine, Cardiology, Hematology +13

Thromboxanes: Selective Biosynthesis and Distinct Biological Properties

Philip Needleman, Mark S. Minkes, Amiram Raz · Science · 1976 · 390 citations

Medicine, Biochemistry, Pharmacology +17

Antagonism of the effects of furosemide by in domethacin in normal and hypertensive man

Ram V. Patak, Basab K. Mookerjee, Carl J. Bentzel et al. · Prostaglandins · 1975 · 265 citations

Pharmacy, Pharmacokinetics, Pharmacology +9