Concepedia
Clinical Pharmacology & Therapeutics · 2006 · 241 citations · 19 references
Overall, when used appropriately, microdosing offers the potential to aid in early drug candidate selection.
19
The price of innovation: new estimates of drug development costs
Joseph A. DiMasi, Ronald W. Hansen, Henry G. Grabowski · Journal of Health Economics · 2003 · 4.3K citations
Economics, Pharmaceutical Innovation, Applied Economics +11
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*
Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 616 citations
Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution
Svein Øie, Thomas N. Tozer · Journal of Pharmaceutical Sciences · 1979 · 253 citations
Protein Folding, Apparent Volume, Physiology +2
STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN*
Robert A. O’Reilly, Paul M. Aggeler, Lois S. Leong · Journal of Clinical Investigation · 1963 · 208 citations · Full text
Tissue Distribution of Basic Drugs: Accounting for Enantiomeric, Compound and Regional Differences Amongst β-Blocking Drugs in Rat
Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2005 · 130 citations
Molecular Pharmacology, Pharmacological Study, Medicine +9