Concepedia

Microdosing Pharmacokinetics

Microdosing Pharmacokinetics is a methodological approach within pharmacokinetic research that involves the administration of subtherapeutic doses of a drug to characterize its absorption, distribution, metabolism, and excretion while minimizing pharmacological effects and ethical risks associated with higher dosing.

29

Publications

1.1K

Citations

190

Authors

77

Institutions

Publications per year

2017–2026

7

Parents

Publications

29

Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs

Graham Lappin, W. Kuhnz, R. Jochemsen et al. · Clinical Pharmacology & Therapeutics · 2006 · 242 citations · Full text

, , +13

EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE

Punam Sandhu, John S. Vogel, Mark J. Rose et al. · Drug Metabolism and Disposition · 2004 · 65 citations · Full text

, , +16

EVALUATION OF MICRODOSING TO ASSESS PHARMACOKINETIC LINEARITY IN RATS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

Suresh K. Balani, N. Nagaraja, Mark G. Qian et al. · Drug Metabolism and Disposition · 2005 · 61 citations

, , +16

A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer’s disease

Martin Bauer, Oliver Langer, Peter Dal‐Bianco et al. · Clinical Pharmacology & Therapeutics · 2006 · 53 citations · Full text

, , +16

American College of Clinical Pharmacology Position Statement on the Use of Microdosing in the Drug Development Process

Joseph Bertino, Howard Greenberg, Michael D. Reed · The Journal of Clinical Pharmacology · 2007 · 51 citations

, , +15

1–5 of 29

Authors

190

  1. GM
    Gerd Mikus

    Heidelberg University, Germany

    4 publications · 68 citations

    4

    h-index

  2. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    4 publications · 86 citations

    4

    h-index

  3. TB
    Tal Burt

    Columbia University, United States

    3 publications · 38 citations

    3

    h-index

  4. SB
    Sieto Bosgra

    Utrecht University, Netherlands

    2 publications · 58 citations

    2

    h-index

  5. JB
    Jürgen Burhenne

    Heidelberg University, Germany

    2 publications · 37 citations

    2

    h-index

1–5 of 190

Institutions

77

  1. Heidelberg University

    Heidelberg, Germany

    4 h-index

    14 publications

    250 citations

  2. University of Manchester

    Manchester, United Kingdom

    3 h-index

    11 publications

    2.2K citations

  3. University Hospital Heidelberg

    Heidelberg, Germany

    3 h-index

    12 publications

    226 citations

  4. Lawrence Livermore National Laboratory

    Livermore, United States

    3 h-index

    12 publications

    404 citations

  5. The University of Tokyo

    Tokyo, Japan

    3 h-index

    6 publications

    122 citations

  6. Medical University of Vienna

    Vienna, Austria

    2 h-index

    19 publications

    989 citations

  7. RIKEN Center for Integrative Medical Sciences

    Yokohama, Japan

    2 h-index

    2 publications

    33 citations

  8. Duke University

    Durham, United States

    2 h-index

    15 publications

    160 citations

1–8 of 77

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 3 publications · 320 citations

    3

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 2 publications · 32 citations

    2

    h-index

  3. Journal of Nuclear Medicine

    2 publications · 62 citations

    2

    h-index

  4. European Journal of Pharmaceutical Sciences

    2 publications · 70 citations

    2

    h-index

  5. Drug Metabolism and Disposition

    2 publications · 126 citations

    2

    h-index

1–5