A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

Mark E. Dudley, John R. Wunderlich, Paul F. Robbins et al. · Science · 2002 · 2.8K citations · Full text

Life Sciences, Immunology, Oncology +17

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Zelig Eshhar, Tova Waks, G. Gross et al. · Proceedings of the National Academy of Sciences · 1993 · 1.6K citations

Life Sciences, Immunology, Oncology +17

Adoptive T cell therapy using antigen-specific CD8 ⁺ T cell clones for the treatment of patients with metastatic melanoma: <i>In vivo</i> persistence, migration, and antitumor effect of transferred T cells

Cassian Yee, John A. Thompson, D. Byrd et al. · Proceedings of the National Academy of Sciences · 2002 · 1.2K citations

Medicine, Immunology, Oncology +17

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

John Maher, Renier J. Brentjens, Gertrude Gunset et al. · Nature Biotechnology · 2002 · 1K citations

Life Sciences, Cell Biology, Immunology +13

Treatment of Patients With Metastatic Melanoma With Autologous Tumor-Infiltrating Lymphocytes and Interleukin 2

Steven A. Rosenberg, John R. Yannelli, James Chih‐Hsin Yang et al. · JNCI Journal of the National Cancer Institute · 1994 · 1K citations

Medicine, Immunology, Oncology +15