Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APPE693Q mice through reduction of ganglioside-bound Aβ

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

Ulrich S. Schubert, Luis C. Antón, James S. Gibbs et al. · Nature · 2000 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +13

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

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GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

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Life Sciences, Biochemistry, Neuroscience +12

Cholesterol-dependent Formation of GM1 Ganglioside-bound Amyloid β-Protein, an Endogenous Seed for Alzheimer Amyloid

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Life Sciences, Biochemistry, Neuroscience +17