Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

John Eng, Wayne Kleinman, L Singh et al. · Journal of Biological Chemistry · 1992 · 984 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

Daniel J. Cuthbertson, Andrew J. Irwin, Chris J. Gardner et al. · PLoS ONE · 2012 · 224 citations · Full text

Medicine, Endocrinology, Pharmacotherapy +17

Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes

Gary Meininger, Russell Scott, Maria Alba et al. · Diabetes Care · 2011 · 217 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13

Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study

Riccardo C. Bonadonna, Tim Heise, Christophe Arbet‐Engels et al. · The Journal of Clinical Endocrinology & Metabolism · 2010 · 143 citations · Full text

Medicine, Endocrinology, Physiology +14

Hepatic Glucokinase Expression Is Associated with Lipogenesis and Fatty Liver in Humans

Andreas Peter, Norbert Stefan, Alexander Čegan et al. · The Journal of Clinical Endocrinology & Metabolism · 2011 · 120 citations · Full text

Life Sciences, Biochemistry, Molecular Genetics +15