Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines

Rajesh Bahekar, Mukul R. Jain, Pradip Jadav, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineAntidiabetic ActivityPharmacological AgentHeterocycle Chemistry +3

Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines

Rajesh Bahekar, Mukul R. Jain, Ashish Goel, +5

Bioorganic & Medicinal Chemistry

Bioorganic ChemistryMedicineBiological EvaluationPharmacologyDerivative (Chemistry) +3

Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors

Dipam Patel, Mukul R. Jain, Shailesh R. Shah, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioavailable Triaryl-sulfonamidePharmaceutical ScienceBiochemistryMedicine +10

Coagonist of GLP-1 and Glucagon Receptor Ameliorates Development of Non-Alcoholic Fatty Liver Disease

Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, +9

Cardiovascular & Hematological Agents in Medicinal Chemistry

Synthesis and Antidiabetic Activity of 3,6,7‐Trisubstituted‐2‐(1<i>H</i>‐imidazol‐2‐ylsulfanyl)quinoxalines and Quinoxalin‐2‐yl isothioureas

Rajesh Bahekar, Mukul R. Jain, Arun A. Gupta, +5

Archiv der Pharmazie

Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect

Nirav Dhanesha, Amit Joharapurkar, Gaurang Shah, +4

Pharmacological Reports

GlycobiologyInsulin SignalingMetabolic SyndromeInsulin DeliveryHealth Sciences +14

Synthesis and Anticonvulsant Activity of 3-(6-Substituted-benzothiazol-2-yl)-6-phenyl-[1, 3]-xazinane-2-thiones

Rajendra S. Chopade, Rajesh Bahekar, Pramod B. Khedekar, +2

Archiv der Pharmazie

Medicinal ChemistryHeterocyclicPharmacological StudyMedicineC Nmr +11

Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice

Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, +5

Canadian Journal of Physiology and Pharmacology

Food IntakeCaloric RestrictionGlucose ToleranceInsulin SignalingGastrointestinal Peptide Hormone +18

Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice

Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, +7

Pharmacological Reports

Metabolic SyndromeType 1Diabetes ManagementMedicineLiver Physiology +11

Long-acting peptidomimetics based DPP-IV inhibitors

Pradip Jadav, Rajesh Bahekar, Shailesh R. Shah, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDpp-iv InhibitorsMedicinePeptoidRational Drug Design +3