PLoS ONE · 2010 · 54 citations · 73 references
Our current study uncovers a developmental pathway involving Chp/PAK/PIX signaling, which helps co-ordinate E-cadh disposition to promote proper cell adhesiveness, and coordinate movements of the three major cell layers in epiboly. Our data shows that without Chp signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement. These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier.
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Stages of embryonic development of the zebrafish
Charles B. Kimmel, William W. Ballard, Seth R. Kimmel et al. · Developmental Dynamics · 1995 · 12K citations
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Edward Manser, Thomas Leung, Harfizah Salihuddin et al. · Nature · 1994 · 1.5K citations
Signal Transduction, Molecular Neuroscience, Molecular Physiology +8