Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Guoping Feng, Rebecca H. Mellor, M. Bernstein et al. · Neuron · 2000 · 3.1K citations · Full text

Molecular Neuroscience, Neurogenomics, Neurophysiology +13

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlákur Jónsson, Jasvinder K. Atwal, Stacy Steinberg et al. · Nature · 2012 · 1.7K citations

Neurodegenerative Diseases, Alzheimer's Disease, Aging +10

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Pascale N. Lacor, Maria C. Buniel, Paul W. Furlow et al. · Journal of Neuroscience · 2007 · 1.2K citations · Full text

Transient and Persistent Dendritic Spines in the Neocortex In Vivo

Anthony Holtmaat, Joshua T. Trachtenberg, Linda Wilbrecht et al. · Neuron · 2005 · 1.1K citations · Full text

Synaptic Plasticity, Dendritic Spines, Neurophysiology +11

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1K citations

Protein Secretion, Signal Transduction, Molecular Neuroscience +8