Concepedia

Post-Translational Inhibition of IP-10 Secretion in IEC by Probiotic Bacteria: Impact on Chronic Inflammation

Gabriele Hörmannsperger, Thomas Clavel, Micha Hoffmann, Caroline Reiff, D. F. Kelly, Gunnar Loh, Michaël Blaut, Gabriele Hölzlwimmer, Melanie Laschinger, Dirk Haller

PLoS ONE · 2009 · 78 citations · 48 references

DOIFull text

Open access

Abstract

We demonstrate segment specific effects of probiotic intervention that correlate with reduced IP-10 protein expression in the native epithelium. Furthermore, we revealed post-translational degradation of IP-10 protein in IEC to be the molecular mechanism underlying the anti-inflammatory effect.

References

48

A new mathematical model for relative quantification in real-time RT-PCR

Michael W. Pfaffl · Nucleic Acids Research · 2001 · 34.3K citations · Full text

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

Frank L. Graham, W. C. Russell, James R. Smiley et al. · Journal of General Virology · 1977 · 4.8K citations

, , +11

Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

Edward V. Loftus · Gastroenterology · 2004 · 3.1K citations · Full text

, , +7

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Paolo Gionchetti, Fernando Rizzello, Alessandro Venturi et al. · Gastroenterology · 2000 · 1.5K citations

, , +6

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Dimitris L. Kontoyiannis, Manolis Pasparakis, Theresa T. Pizarro et al. · Immunity · 1999 · 1.3K citations · Full text

, , +10