Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

Functional domains of the human glucocorticoid receptor

Vincent Giguère, Stanley M. Hollenberg, Michael G. Rosenfeld et al. · Cell · 1986 · 927 citations

Functional Domains, Signal Transduction, G Protein-coupled Receptor +8

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Anke Geick, Michel Eichelbaum, Oliver Burk · Journal of Biological Chemistry · 2001 · 840 citations · Full text

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Timothy W. Synold, Isabelle Dussault, Barry M. Forman · Nature Medicine · 2001 · 828 citations

Signal Transduction, Signaling Pathway, Molecular Pathway +6

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

Linda B. Moore, Derek J. Parks, Stacey A. Jones et al. · Journal of Biological Chemistry · 2000 · 808 citations · Full text

Pregnane X Receptor, Signal Transduction, Pxr Activator Clotrimazole +15

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

T D Porter, Minor J. Coon · Journal of Biological Chemistry · 1991 · 679 citations · Full text

Cellular Enzymology, Biochemistry, Natural Sciences +5