Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Alexander L. Klibanov, Kazuo Maruyama, Vladimir P. Torchilin et al. · FEBS Letters · 1990 · 2K citations · Full text

Pharmacy, Pharmaceutics, Pharmacokinetics +17

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

Marc Dellian, Dai Fukumura, Michael Leunig et al. · PubMed · 1995 · 1.7K citations

Medicine, Cancer Biology, Oncology +17

Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2

Tamar Safra, Franco M. Muggia, Susan Jeffers et al. · Annals of Oncology · 2000 · 613 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro

Philip S. Low · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1995 · 572 citations

Pharmacy, Molecular Pharmaceutics, Pharmacology +14