Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer’s disease

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Treatment of Alzheimer's disease; current status and new perspectives

Elio Scarpini, Philip Schelterns, Howard Feldman · The Lancet Neurology · 2003 · 725 citations

Medicine, Neurology, Pharmacotherapy +14

Development of synthetic compounds with glutathione peroxidase activity

Stephen R. Wilson, Paul A. Zucker, R R Huang et al. · Journal of the American Chemical Society · 1989 · 409 citations

Natural Sciences, Biochemistry, Chemistry +13

Neuroprotective Effect of an Antioxidant, Ebselen, in Patients with Delayed Neurological Deficits after Aneurysmal Subarachnoid Hemorrhage

Isamu Saito, Takao Asano, Keiji Sano et al. · Neurosurgery · 1998 · 259 citations

Medicine, Neurology, Neurosurgery +17

Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

Ferry Hagen, Paulo Cézar Ceresini, Itzhack Polacheck et al. · PLoS ONE · 2013 · 221 citations · Full text

Life Sciences, Biology, Microbiology +17