Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

Chuan‐Jun Lu, Yueyan Guo, Jun Yan, +5

Journal of Medicinal Chemistry

Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen

Zonghua Luo, Jianfei Sheng, Yang Sun, +6

Journal of Medicinal Chemistry

Combinatorial ChemistryNeurochemical BiomarkersAlzheimer ’Experimental PharmacologyCholinesterase Inhibitor Donepezil +17

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

Ling Huang, Chuan‐Jun Lu, Yang Sun, +6

Journal of Medicinal Chemistry

Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer’s disease

Huailei Jiang, Xu Wang, Ling Huang, +4

Bioorganic & Medicinal Chemistry

Alzheimer's DiseaseMedicinePharmacological AgentPharmacologyBenzenediol-berberine Hybrids

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids

Ling Huang, Tao Su, Wenjun Shan, +4

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseCholinesterase ActivityBiochemistryMedicine +7

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer’s disease

Zonghua Luo, Liang Liang, Jianfei Sheng, +4

Bioorganic & Medicinal Chemistry

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryEbselen DerivativesMedicine +6

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation

Fei Mao, Ling Huang, Zonghua Luo, +3

Bioorganic & Medicinal Chemistry

O-amino Benzylamine-tacrine HybridsCombinatorial ChemistryCholinesterase ActivityBiochemistryNatural Sciences +6

Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity

Fei Mao, Jianwen Chen, Qi Zhou, +3

Bioorganic & Medicinal Chemistry Letters

Novel Tacrine–ebselen HybridsBiochemistryNatural SciencesMedicineChemical Biology +4

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

Hui Liu, Hongjun Jin, Xuyi Yue, +4

Molecular Imaging and Biology

Neuroimaging BiomarkersPet Imaging StudyS1pr1 ExpressionNeurological DisorderNeurology +2

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase

Ling Huang, Zonghua Luo, Feng He, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBerberine DerivativesBiochemistryDual InhibitorsNatural Sciences +8