Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Philippe Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell · 1991 · 2K citations

Sclerostin, Developmental Biology, Bone Morphogenic Protein +7

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

Masao Ono, Silvia Bolland, Paul Tempst et al. · Nature · 1996 · 780 citations

Inflammation, Signal Transduction, Immune Cell Development +14

Defective B cell development and function in Btk-deficient mice

Wasif N. Khan, Frederick W. Alt, Rachel M. Gerstein et al. · Immunity · 1995 · 724 citations · Full text

Knockout Mouse, Developmental Biology, Lymphocyte Development +9

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Martin Turner, P. Joseph Mee, Patrick Costello et al. · Nature · 1995 · 721 citations

Developmental Biology, Signaling Pathway, Cell Regulation +12

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

Margaret L. Hibbs, David M. Tarlinton, Jane E. Armes et al. · Cell · 1995 · 697 citations · Full text

Immunogenetics, Lyn-deficient Mice, Autoimmune Disease +12