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Structure-based design and synthesis of pyrazinones containing novel P1 ‘side pocket’ moieties as inhibitors of TF/VIIa

Barbara A. Schweitzer, William L. Neumann, Hayat Rahman, Carrie L. Kusturin, Kirby R. Sample, Gennadiy Poda, Ravi G. Kurumbail, Anna M. Stevens, Roderick A. Stegeman, William C. Stallings,

Bioorganic & Medicinal Chemistry Letters · 2005 · 17 citations · 15 references

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References

15

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

David W. Banner, A. D’Arcy, C. Chene et al. · Nature · 1996 · 729 citations

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Thromboresistance of Balloon-Injured Porcine Carotid Arteries After Local Gene Transfer of Human Tissue Factor Pathway Inhibitor

Pierre Zoldhelyi, J McNatt, Harnath Shelat et al. · Circulation · 2000 · 93 citations · Full text

Active site-blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model.

Claude R. Benedict, J Ryan, B A Wolitzky et al. · Journal of Clinical Investigation · 1991 · 91 citations · Full text

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Thrombin Inhibitor Design

Philip E.J. Sanderson, A. M. Naylor-Oisen · Current Medicinal Chemistry · 1998 · 82 citations

, , +19

Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

John J. Parlow, Brenda L. Case, Thomas A. Dice et al. · Journal of Medicinal Chemistry · 2003 · 71 citations · Full text

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