Concepedia

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases

Yuko Kato, Nobuhiro Fuchi, Yutaka Nishimura, Ayano Watanabe, Mai Yagi, Yasuhito Nakadera, Eriko Higashi, Masateru Yamada, Takumi Aoki, Hideo Kigoshi

Bioorganic & Medicinal Chemistry Letters · 2013 · 10 citations · 5 references

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References

5

Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

Xueying Zhao, Tatsuo Yamamoto, John W. Newman et al. · PubMed · 2004 · 222 citations

, , +17

Human soluble epoxide hydrolase: Structural basis of inhibition by 4‐(3‐cyclohexylureido)‐carboxylic acids

G. Gomez, Christophe Morisseau, Bruce D. Hammock et al. · Protein Science · 2005 · 101 citations · Full text

, , +17

Cytosolic epoxide hydrolase in humans: development and tissue distribution

G. M. Pacifici, A. Temellini, L. Giuliani et al. · Archives of Toxicology · 1988 · 52 citations

, , +9

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension

Yuko Kato, Nobuhiro Fuchi, Hajime Saburi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · Full text

, , +16

Proteinuria and the Fragility of Normal and Diseased Glomerular Basement Membrane

Cecil A. Krakower, B. K. Nicholes, S. A. Greenspon · Experimental Biology and Medicine · 1978 · 11 citations

, , +11