Mai Yagi

HIS-388, a Novel Orally Active and Long-Acting 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Ameliorates Insulin Sensitivity and Glucose Intolerance in Diet-Induced Obesity and Nongenetic Type 2 Diabetic Murine Models

Seiji Okazaki, Takehiro Takahashi, Tomokatsu Iwamura et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 21 citations

Medicine, Endocrinology, Pharmacology +17

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension

Yuko Kato, Nobuhiro Fuchi, Hajime Saburi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases

Yuko Kato, Nobuhiro Fuchi, Yutaka Nishimura et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 10 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13