Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Genetics, Cyp3a4 Gene, Mouse Pxr Reveals +18

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Steroid Metabolism, Developmental Biology, Signal Transduction +8

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.3K citations · Full text

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 936 citations · Full text

Pharmacotherapy, Oxidative Stress, Gastrointestinal Peptide Hormone +21

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

Wen Xie, Anna Radomińska‐Pandya, Yanhong Shi et al. · Proceedings of the National Academy of Sciences · 2001 · 747 citations · Full text

Lipid Peroxidation, Molecular Biology, Xenobiotic Receptor +24