Effects of Shear Stress on Eicosanoid Gene Expression and Metabolite Production in Vascular Endothelium as Studied in a Novel Biomechanical Perfusion Model

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

Piotr Chomczyński · PubMed · 1993 · 2.8K citations

Life Sciences, Biochemistry, Molecular Biology +17

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

John A. Frangos, Suzanne G. Eskin, Larry V. McIntire et al. · Science · 1985 · 1.2K citations

Life Sciences, Pharmacology, Physiology +12

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

James N. Topper, Jiexing Cai, D Falb et al. · Proceedings of the National Academy of Sciences · 1996 · 840 citations

Life Sciences, Physiology, Biomechanics +14

Nitric Oxide Synthesis by Cultured Endothelial Cells Is Modulated by Flow Conditions

Marina Noris, Marina Morigi, Roberta Donadelli et al. · Circulation Research · 1995 · 542 citations

Life Sciences, Cell Biology, Physiology +12