Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Metabolic Regulation of Brain Aβ by Neprilysin

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Science · 2001 · 944 citations

Aging, Neurochemical Biomarkers, Amyloid Beta Peptide +19

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Nature Medicine · 2000 · 856 citations

Neurodegenerative Diseases, Synaptic Signaling, Degenerative Pathology +9

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Wei Qiao Qiu, Dominic M. Walsh, Zhen Ye et al. · Journal of Biological Chemistry · 1998 · 797 citations · Full text

A Strategy for the Generation of Surfaces Presenting Ligands for Studies of Binding Based on an Active Ester as a Common Reactive Intermediate: A Surface Plasmon Resonance Study

Joydeep Lahiri, Lyle Isaacs, Joe Tien et al. · Analytical Chemistry · 1999 · 599 citations

Engineering, Active Ester, Chemistry +19