Concepedia

Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes

Otto O. Yang, Holly Lin, Mirabelle Dagarag, Hwee L. Ng, Rita B. Effros, Christel H. Uíttenbogaart

Virology · 2004 · 76 citations · 13 references

DOI

Concepts

References

13

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

Stephen A. Migueles, Alisha C. Laborico, W. Lesley Shupert et al. · Nature Immunology · 2002 · 988 citations

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Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

Michael R. Betts, David R. Ambrozak, Daniel C. Douek et al. · Journal of Virology · 2001 · 685 citations · Full text

, , +17

Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load

Marylyn M. Addo, Xu G. Yu, Almas Rathod et al. · Journal of Virology · 2003 · 662 citations · Full text

, , +17

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

Rita B. Effros, Richard Allsopp, Choy‐Pik Chiu et al. · AIDS · 1996 · 460 citations

, , +15

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

Otto O. Yang, Spyros A. Kalams, Alicja Trocha et al. · Journal of Virology · 1997 · 340 citations · Full text

, , +17