Essential role of stromally induced hedgehog signaling in B-cell malignancies

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Knockout Mouse, Spontaneous Tumours, Medicine +9

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Jerry M. Adams, A. W. Harris, Carl A. Pinkert et al. · Nature · 1985 · 1.8K citations

Lymphoid Neoplasia, Immunogenetics, Autoimmune Disease +7

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Riccardo Dalla‐Favera, Marco Bregni, J Erikson et al. · Proceedings of the National Academy of Sciences · 1982 · 1.8K citations

Complete Gene, Genetics, Immunology +16

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Michio Kawano, Toshio Hirano, Tadashi Matsuda et al. · Nature · 1988 · 1.7K citations

Hematological Malignancy, Immunology, Hematology +7

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Manuel Serrano, Han‐Woong Lee, Lynda Chin et al. · Cell · 1996 · 1.6K citations · Full text

Oncology, Cell Mortality, Medicine +11