Exploiting biological complexity for strain improvement through systems biology

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

Paul Shannon, Andrew Markiel, Owen Ozier et al. · Genome Research · 2003 · 52.1K citations · Full text

Transcriptional Regulatory Networks in <i>Saccharomyces cerevisiae</i>

Tong Ihn Lee, Nicola J. Rinaldi, François Robert et al. · Science · 2002 · 3K citations

Genetics, Gene Regulatory Network, Gene Transcription +20

Comparative assessment of large-scale data sets of protein–protein interactions

Christian von Mering, Roland Krause, ‎Berend Snel et al. · Nature · 2002 · 2.4K citations

Protein–protein Interactions, Engineering, Interactomics +7

Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

Trey Ideker, Vésteinn Thórsson, Jeffrey A. Ranish et al. · Science · 2001 · 2.1K citations

Genetics, Molecular Biology, Metabolic Model +20

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Vincent J. J. Martin, Douglas J. Pitera, Sydnor T. Withers et al. · Nature Biotechnology · 2003 · 1.7K citations

Biomanufacturing, Biosynthesis, Engineering +13