Fragment-based strategy for structural optimization in combination with 3D-QSAR

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 5.8K citations

Medicinal Chemistry, Medicine, Natural Sciences +9

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

Richard D. Cramer, David E. Patterson, Jeffrey D. Bunce · Journal of the American Chemical Society · 1988 · 3.9K citations

Proteinlipid Interaction, Protein Assembly, Altmetric Attention Score +18

Molecular Similarity Indices in a Comparative Analysis (CoMSIA) of Drug Molecules to Correlate and Predict Their Biological Activity

G. Klebe, Ute Abraham, Thomas Mietzner · Journal of Medicinal Chemistry · 1994 · 1.8K citations

New Method for Fast and Accurate Binding‐site Identification and Analysis

Tom Halgren · Chemical Biology & Drug Design · 2007 · 886 citations

Drug Target, Hit Identification, Structural Bioinformatics +19

An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Helen Y. Zou, Qiuhua Li, Joseph H. Lee et al. · Cancer Research · 2007 · 746 citations · Full text

Tumor Biology, C-met Kinase, Chemoprevention Strategy +15