Shihe Hu

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

I. Ross Garrett, D. Chen, Gabriel Gutiérrez et al. · Journal of Clinical Investigation · 2003 · 333 citations · Full text

Proteasome Inhibitors, Ubiquitin-proteasome Machinery, Sclerostin +13

N‐Heterocyclic Carbene‐Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin‐3‐ones with a Tetrasubstituted Carbon Stereocenter

Junyu Xu, Shihe Hu, Yingyan Lu et al. · Advanced Synthesis & Catalysis · 2015 · 47 citations

Chemical Engineering, Diversity Oriented Synthesis, Engineering +13

Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors

Haoliang Yuan, Qiufeng Liu, Li Zhang et al. · European Journal of Medicinal Chemistry · 2017 · 44 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +9

Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants

Haoyang Zhang, Wenkui Wu, Chao Feng et al. · European Journal of Medicinal Chemistry · 2017 · 38 citations · Full text

L858r/t790m Double Mutants, Vivo Evaluation, Sar Discussion +6

N-Heterocyclic carbene-catalyzed annulation of cyclic β-enamino esters with enals: access to functionalized indolo[2,3-a]quinolizidines

Shihe Hu, Bingyang Wang, Yu Zhang et al. · Organic & Biomolecular Chemistry · 2015 · 36 citations