Concepedia

Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity

Harish Kommera, Goran N. Kaluđerović, Sebastian Dittrich, Jutta Kalbitz, Birgit Dräger, Thomas Mueller, Reinhard Paschke

Bioorganic & Medicinal Chemistry Letters · 2010 · 62 citations · 18 references

DOI

Concepts

References

18

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

, , +10

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

, , +14

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Valentina Zuco, Rosanna Supino, Sabina Carla Righetti et al. · Cancer Letters · 2002 · 530 citations

, , +4

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Simone Fulda, Carsten Scaffidi, Santos A. Susín et al. · Journal of Biological Chemistry · 1998 · 374 citations · Full text

, , +17

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations · Full text

, , +17