Clinical Monitoring of Tacrolimus after Liver Transplantation Using Pentamer Formation Assay and Microparticle Enzyme Immunoassay

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Neil A. Clipstone · Nature · 1992 · 1.6K citations

Life Sciences, Immunology, Molecular Biology +12

Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.

Kenji Iwasaki, Toshifumi Shiraga, H Matsuda et al. · Drug Metabolism and Disposition · 1995 · 105 citations

Life Sciences, Biochemistry, Pharmacology +17

Interaction of Tacrolimus (FK506) and Its Metabolites with FKBP and Calcineurin

Kouichi Tamura, Tsutomu Fujimura, Kaname IWASAKI et al. · Biochemical and Biophysical Research Communications · 1994 · 61 citations

Pharmacy, Pharmacokinetics, Pharmacology +9

High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients.

Uwe Christians, F Braun, N Kosian et al. · PubMed · 1991 · 44 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +14

Modified pentamer formation assay for measurement of tacrolimus and its active metabolites: comparison with liquid chromatography–tandem mass spectrometry and microparticle enzyme-linked immunoassay (MEIA-II)

Victor W. Armstrong, Ekkehard Schuetz, Qingling Zhang et al. · Clinical Chemistry · 1998 · 31 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17