Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Protein Function, Signal Transduction, Biochemistry +9

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

Robert E. Handschumacher, Matthew W. Harding, Jeffrey S. Rice et al. · Science · 1984 · 1.7K citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

W. Michael Flanagan, Blaise Corthésy, Richard J. Bram et al. · Nature · 1991 · 1.1K citations

Transcriptional Regulation, Signal Transduction, Cell Regulation +12

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

Barbara E. Bierer, Petri S. Mattila, Robert F. Standaert et al. · Proceedings of the National Academy of Sciences · 1990 · 708 citations · Full text

T-regulatory Cell, Dissociation Constant, Immune Regulation +19

Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

J Berger, Joachim Hauber, Regina Hauber et al. · Gene · 1988 · 682 citations

Oocyte, Developmental Biology, Placental Development +13