Concepedia

A survival–stratification model of human colorectal carcinomas with β‐catenin and p27<sup>kip1</sup>

Peh Yean Cheah, Poh Heok Choo, Jocelyn Yao, Kong Weng Eu, Francis Seow‐Choen

Cancer · 2002 · 52 citations · 31 references

DOIFull text

Open access

Abstract

The combined expression of beta-catenin and p27 can stratify patients into markedly different survival groups, possibly via their antagonistic effects on metastasis promotion.

References

31

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Osamu Tetsu, Frank McCormick · Nature · 1999 · 3.6K citations

, , +10

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

Michael Shtutman, Jacob Zhurinsky, Inbal Simcha et al. · Proceedings of the National Academy of Sciences · 1999 · 2.2K citations · Full text

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

Massimo Loda, Barry Cukor, Sun W. Tam et al. · Nature Medicine · 1997 · 1K citations

, , +8

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

Thomas Brabletz, Andreas Jung, Simone Reu et al. · Proceedings of the National Academy of Sciences · 2001 · 1K citations · Full text

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

Peggy L. Porter, Kathleen E. Malone, Patrick J. Heagerty et al. · Nature Medicine · 1997 · 918 citations

, , +9