Metabolism of ethylbenzene by human liver microsomes and recombinant human cytochrome P450s (CYP)

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

F. Peter Guengerich, Dong‐Hyun Kim, M. Iwasaki · Chemical Research in Toxicology · 1991 · 1.2K citations

Medicine, Oncology, Toxicology +8

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

Medicine, Pharmacokinetics, Pharmacology +17

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

Victoria A. Eagling, John Tjia, David Back · British Journal of Clinical Pharmacology · 1998 · 336 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes.

Nathalie Chauret, Annick Gauthier, Deborah A. Nicoll‐Griffith · PubMed · 1998 · 310 citations

Medicine, Biochemistry, Pharmacology +16

Effect of Methanol, Ethanol, Dimethyl Sulfoxide, and Acetonitrile on In Vitro Activities of cDNA-Expressed Human Cytochromes P-450

William F. Busby, Joseph M. Ackermann, Charles L. Crespi · Drug Metabolism and Disposition · 1999 · 302 citations

Medicine, Biochemistry, Pharmacology +17