Concepedia

Synthesis of Antioxidants for Prevention of Age-Related Macular Degeneration

Dharati Joshi, James B. Field, John D. Murphy, Heike Schönherr, Janet R. Sparrow, George A. Ellestad, Koji Nakanishi, Arie Zask

Journal of Natural Products · 2013 · 36 citations · 14 references

DOIFull text

Open access

Concepts

Abstract

Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.

References

14

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, , +17