Concepedia

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

Shaun R. Selness, Rajesh Devraj, Balekudru Devadas, John K. Walker, Terri L. Boehm, Richard C. Durley, H.-S. Shieh, Paul V. Rucker, Kevin D. Jerome, Alan G. Benson,

Bioorganic & Medicinal Chemistry Letters · 2011 · 72 citations · 9 references

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9

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

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Efficacy, pharmacodynamics, and safety of VX‐702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double‐blind, placebo‐controlled clinical studies

Nemanja Damjanov, Robert S. Kauffman, G Spencer-Green · Arthritis & Rheumatism · 2009 · 246 citations

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Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Jerry L. Adams, Jeffrey C. Boehm, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 113 citations · Full text

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Potential of p38 inhibitors in the treatment of rheumatoid arthritis.

M. Foster, F. HALLEY, JE Souness · PubMed · 2000 · 71 citations

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Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

Heidi R. Hope, Gary D. Anderson, Barry Burnette et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 60 citations

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