Heidi R. Hope

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

Heidi R. Hope, Linda J. Pike · Molecular Biology of the Cell · 1996 · 241 citations · Full text

Proteinlipid Interaction, Lipid Biophysics, Phosphoinositide-utilizing Enzymes +19

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

Chun Wang, Susan L. Hockerman, E. Jon Jacobsen et al. · The Journal of Experimental Medicine · 2018 · 98 citations · Full text

Development and Comparison of Two 3T3-L1 Adipocyte Models of Insulin Resistance: Increased Glucose Flux vs Glucosamine Treatment

Stuart A. Ross, Xiaoli Chen, Heidi R. Hope et al. · Biochemical and Biophysical Research Communications · 2000 · 64 citations

Obesity, Metabolic Syndrome, Insulin Resistance +12

Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

Heidi R. Hope, Gary D. Anderson, Barry Burnette et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 60 citations