The use of labile base protecting groups in oligoribonucleotide synthesis

Polymer support oligonucleotide synthesis XVIII^1.2): use of<i>β</i>-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

N. D. SINHA, J. Biernat, J. F. A. McManus et al. · Nucleic Acids Research · 1984 · 848 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +16

<b>Studies on Polynucleotides. XXIV.</b>¹ <b>The Stepwise Synthesis of Specific Deoxyribopolynucleotides (4).</b>² <b>Protected Derivatives of Deoxyribonucleosides and New Syntheses of Deoxyribonucleoside-3″ Phosphates</b>³

Heinz Schaller, G. Weimann, B. Lerch et al. · Journal of the American Chemical Society · 1963 · 402 citations

Pharmacy, Biochemistry, Enzymology +7

Transient protection: efficient one-flask syntheses of protected deoxynucleosides

Gavrilova Ti, Barbara L. Gaffney, Roger A. Jones · Journal of the American Chemical Society · 1982 · 389 citations

Pharmacy, Chemistry, Analytical Chemistry +4

<i>In situ</i>activation of bis-dialkylaminophosphines—a new method for synthesizing deoxyoligonucleotides on polymer supports

Anthony D. Barone, Jin Tang, Marvin H. Caruthers · Nucleic Acids Research · 1984 · 242 citations · Full text

Natural Sciences, Chemistry, Polymer Chemistry +10

The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups

J.C. Schulhof, D. Molko, R. Téoule · Nucleic Acids Research · 1987 · 199 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +13