Concepedia

Base-labile Linkers

Base-Labile Linkers is a type of chemical linker designed to remain stable under acidic and neutral conditions but selectively cleaved under basic conditions, thereby enabling controlled release of attached molecules in synthetic and bioconjugation applications.

31

Publications

1K

Citations

117

Authors

43

Institutions

Publications per year

2017–2026

3

Parents

Publications

31

Use of a Temporary “Solubilizing” Peptide Tag for the Fmoc Solid-Phase Synthesis of Human Insulin Glargine via Use of Regioselective Disulfide Bond Formation

Mohammed Akhter Hossain, Alessia Belgi, Feng Lin et al. · Bioconjugate Chemistry · 2009 · 94 citations

, , +15

Traceless Solid-Phase Synthesis of Substituted Benzimidazoles via a Base-Cleavable Linker

David Tumelty, Kathy Y. Cao, Christopher P. Holmes · Organic Letters · 2000 · 74 citations

, , +11

The membrane-embedded segment of cytochrome b5 as studied by cross-linking with photoactivatable phospholipids.

Yohtaroh Takagaki, Rahul Radhakrishnan, Chhitar M. Gupta et al. · Journal of Biological Chemistry · 1983 · 73 citations · Full text

, , +17

Solid-Phase Intramolecular <i>N</i>-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity

Thomas E. Nielsen, Morten Meldal · The Journal of Organic Chemistry · 2004 · 71 citations

, , +16

Methylation of carbohydrates bearing base-labile substituents, with diazomethane-boron trifluoride etherate

Jorge O. Deferrari, Eduardo G. Gros, Irma O. Mastronardi · Carbohydrate Research · 1967 · 69 citations

, , +9

1–5 of 31

Authors

117

  1. MS
    Mitsuo Sekine

    Tokyo Institute of Technology, Japan

    3 publications · 56 citations

    3

    h-index

  2. EG
    Eduardo G. Gros

    Fundación Ciencias Exactas y Naturales, Argentina

    2 publications · 90 citations

    2

    h-index

  3. AO
    Akihiro Ohkubo

    Tokyo Institute of Technology, Japan

    2 publications · 30 citations

    2

    h-index

  4. KS
    Kohji Seio

    Tokyo Institute of Technology, Japan

    2 publications · 30 citations

    2

    h-index

  5. GW
    Geoffrey W. Tregear

    The University of Melbourne, Australia

    1 publications · 94 citations

    1

    h-index

1–5 of 117

Institutions

43

  1. Fundación Ciencias Exactas y Naturales

    Buenos Aires, Argentina

    2 h-index

    5 publications

    249 citations

  2. Universidad de Buenos Aires

    Buenos Aires, Argentina

    2 h-index

    5 publications

    249 citations

  3. Tokyo Institute of Technology

    Tokyo, Japan

    2 h-index

    13 publications

    198 citations

  4. Solvay (Netherlands)

    Weesp, Netherlands

    1 h-index

    1 publications

    17 citations

  5. University of Michigan

    Ann Arbor, United States

    1 h-index

    5 publications

    75 citations

  6. Affymax (United States)

    Cupertino, United States

    1 h-index

    3 publications

    222 citations

  7. Protein Research Foundation

    Osaka, Japan

    1 h-index

    5 publications

    120 citations

  8. Humboldt-Universität zu Berlin

    Berlin, Germany

    1 h-index

    3 publications

    36 citations

1–8 of 43

Venues

  1. Organic Letters

    OL · 3 publications · 104 citations

    3

    h-index

  2. Tetrahedron

    3 publications · 76 citations

    3

    h-index

  3. Tetrahedron Letters

    3 publications · 94 citations

    3

    h-index

  4. 2

    h-index

  5. Bioorganic & Medicinal Chemistry

    2 publications · 33 citations

    2

    h-index

1–5